alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol → HCID 20226648, 화합물

HRID 1732107노트

반응식

HRID 1732107 반응식
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].ClC1C=C(C=CC=1)C(OO)=[O:31]>C(Cl)Cl>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[O:11][CH2:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N+:14]=1[O-:31])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 5059alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 20226648HCID 20226648, 화합물수율 37.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 5.0 g (0.015 mol) 2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline and 3.0 g (0.017 mol) m-chloroperoxybenzoic acid in 100 ml CH2Cl2 was stirred at room temperature for a period of 24 hours. The reaction mixture was extracted with dilute NaHCO3 solution, washed with water, dried over MgSO4 and concentrated to dryness under reduced pressure. The residue was triturated with large amounts of ether to obtain a solid. This solid was filtered, washed with ether and dried to give the desired compound (2 g).

후처리

  1. extractionThe reaction mixture was extracted with dilute NaHCO3 solution
  2. washwashed with water
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated to dryness under reduced pressure
  5. customThe residue was triturated with large amounts of ether
  6. customto obtain a solid
  7. filtrationThis solid was filtered
  8. washwashed with ether
  9. customdried

출처 및 근거

ORD 기록
ord-38e7f46ede484771ad4cd0da699b6744
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04625034

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