Propylene Oxide → 1-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

HRID 1732157노트

반응식

HRID 1732157 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH2:16]1[O:19][CH:17]1[CH3:18].C(N(CC)CC)C>C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:16][CH:17]([OH:19])[CH3:18])=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 6378Propylene OxideHCID 8471TriethylamineHCID 109216164-(3-Fluorophenoxy)phenol

생성물 1

HCID 137531881-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
90 °C

실험 절차

A mixture of 6.13 g of p-(m-fluorophenoxy)phenol, 2.79 g of propylene oxide and 0.12 g of triethylamine is stirred at 90° C. for 18 hours. The cooled mixture is subsequently diluted with 100 ml of diethyl ether and washed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time, with 50 ml of water and with 50 ml of saturated sodium chloride solution. After drying over anhydrous sodium sulfate and evaporation there is obtained 1-[p-(m-fluorophenoxy)phenoxy]-2-propanol of melting point 37°-39° C.

후처리

  1. washwashed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. customevaporation there

출처 및 근거

ORD 기록
ord-7d78d94e419c4f73b0189b78574d9a05
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04625048

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