Methanol → N-acetyl-4-(2-methoxy-n-propoxy)piperidine

반응식

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][CH2:11][CH:12]=[CH2:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:14][OH:15]>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][CH2:11][CH:12]([O:15][CH3:14])[CH3:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 887Methanol

HCID 12920043N-acetyl-4-allyloxypiperidine

생성물 1

HCID 20306010N-acetyl-4-(2-methoxy-n-propoxy)piperidine

실험 절차

This compound was prepared similarly to Example F, starting from N-acetyl-4-allyloxypiperidine and mercuric acetate in methanol. To improve the conversion of starting material to product the mercuric acetate/methanol treatment was repeated twice to give N-acetyl-4-(2-methoxy-n-propoxy)piperidine, which was hydrolyzed in sodium hydroxide and methanol solution to give 4-(2-methoxy-n-propoxy)piperidine. A sample was characterized as the oxalate salt, m.p. 89°-91° C.

후처리

customThis compound was prepared similarly to Example F

출처 및 근거

ORD 기록: ord-ec622337630941358cf0f07033a81667
출처 데이터셋: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04237138

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