Sodium Methoxide → HCID 23325026, 화합물

HRID 1732618노트

반응식

HRID 1732618 반응식
Cl.[NH2:2][CH2:3][C:4](=O)[CH2:5][CH2:6][CH2:7][CH3:8].[CH3:10][S:11][C:12](S(C)=O)=[CH:13][N+:14]([O-:16])=[O:15].C[O-].[Na+]>CO>[CH3:10][S:11][C:12]1[NH:2][CH:3]=[C:4]([CH2:5][CH2:6][CH2:7][CH3:8])[C:13]=1[N+:14]([O-:16])=[O:15]

참가 물질

5

반응물 3

HCID 10942334Sodium MethoxideHCID 233250431-Aminohexan-2-one hydrochlorideHCID 544870941-Nitro2-methylthio-2-methylsulphinylethylene

생성물 1

HCID 23325026HCID 23325026, 화합물수율 48.5%

시약·촉매·용매 1

HCID 887Methanol용매3회

실험 절차

1-Amino-2-hexanone hydrochloride (5.8g) was dissolved in methanol (100 ml) and mixed with a solution of 1-methylthio-1-methylsulphinyl-2-nitroethylene (6.8g) in warm methanol (100 ml). A solution of sodium methoxide in methanol (from 1.7g sodium) was added dropwise, with stirring, over 2 hours at 60°, and the mixture was evaporated to dryness. The residue was triturated with water, and the solid was filtered off and dried, to give 2-methylthio-3-nitro-4-n-butylpyrrole (3.9g).

후처리

  1. customthe mixture was evaporated to dryness
  2. customThe residue was triturated with water
  3. filtrationthe solid was filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-7711bf2102ad4720b62e1f6ef17a1793
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04238494

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