Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid monohydrate → 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | 2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate | HCID 86097516 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile | HCID 51041427 | — |
반응 단계
2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737166B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-c5a4eb7304a7465ea090a9d1fd91deef |
| 출처 메모 | uspto-grants-2010_06 |