p-Toluenesulfonic acid monohydrate → 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile

HRID 17329

반응식

HRID 17329 반응식
[C:1]([O:4][C:5]1[C:10]([F:11])=[C:9]([Br:12])[C:8]([CH3:13])=[C:7]([C:14]#[N:15])[C:6]=1[NH2:16])(=O)[CH3:2].O.[C:18]1(C)C=CC(S(O)(=O)=O)=C[CH:19]=1>C1(C)C=CC=CC=1>[Br:12][C:9]1[C:10]([F:11])=[C:5]2[O:4][C:1]([CH:2]3[CH2:19][CH2:18]3)=[N:16][C:6]2=[C:7]([C:14]#[N:15])[C:8]=1[CH3:13]

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 860975162-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate

생성물 1

HCID 510414276-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.

후처리

  1. temperatureunder reflux for 19 hours

출처 및 근거

ORD 기록
ord-c5a4eb7304a7465ea090a9d1fd91deef
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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