Chloroacetonitrile → 3-Amino-6-methylthieno[2,3-b]pyridine-2-carbonitrile

HRID 1732917노트

반응식

HRID 1732917 반응식
[SH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1.C[O-].[Na+].Cl[CH2:15][C:16]#[N:17]>CO>[NH2:9][C:8]1[C:7]2[C:2](=[N:3][C:4]([CH3:10])=[CH:5][CH:6]=2)[S:1][C:15]=1[C:16]#[N:17]

참가 물질

5

반응물 3

HCID 7856ChloroacetonitrileHCID 10942334Sodium MethoxideHCID 178425618HCID 178425618, 화합물

생성물 1

HCID 7023133-Amino-6-methylthieno[2,3-b]pyridine-2-carbonitrile

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 7.5 g. (0.05 mole) of 2-mercapto-3-cyano-6-methylpyridine in 200 ml. of MeOH was added 5.4 g. (0.1 M) sodium methoxide. Stirring was continued until all dissolved. 8.0 g. (0.1 M) of chloroacetonitrile in 20 ml. methanol was then added and the mixture was refluxed for 6 hours. After removal of the solvent, the residue was diluted with water and filtered. The crude product was crystallized from methanol, m.p. 241°-242° C. (Offin No. 2,241,717 in 3/4/74 reported m.p. 241°-243°).

후처리

  1. temperaturethe mixture was refluxed for 6 hours
  2. customAfter removal of the solvent
  3. additionthe residue was diluted with water
  4. filtrationfiltered
  5. customThe crude product was crystallized from methanol, m.p. 241°-242° C. (Offin No. 2,241,717 in 3/4/74 reported m.p. 241°-243°)

출처 및 근거

ORD 기록
ord-dd319e3988c044358deb8d138d602980
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239887

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