Sulfuryl chloride → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 1732943노트

반응식

HRID 1732943 반응식
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([OH:10])[CH:8]=[C:7]([CH3:11])[S:6]1)=[O:4].S(Cl)(Cl)(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH3:11])=[CH:8][C:9]=1[OH:10])=[O:4]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 537769093-Hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester

생성물 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylate수율 75%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

17.4 Parts of 3-hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester are dissolved in 100 parts by volume of methylene chloride. 14.9 parts of sulfuryl chloride in 20 parts by volume of methylene chloride are added in the course of 30 minutes at 10° C., whilst passing nitrogen into the mixture. The mixture is then distilled. 12.9 parts (75% of theory) of 3-hydroxy-5-methylthiophene-2-carboxylic acid methyl ester of boiling point 67°-70° C./0.3 mbar are obtained.

후처리

  1. distillationThe mixture is then distilled

출처 및 근거

ORD 기록
ord-49e6e8169b1c4d8091332137711260ac
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239897

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