HCID 43218479, 화합물 → HCID 20300160, 화합물

반응식

CO[C:3](=[O:16])[CH2:4][CH2:5][S:6][CH2:7][C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O(C)[Na].CO>>[OH:16][CH:3]1[CH:4]=[CH:5][S:6][CH:7]1[C:8](=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

반응물 2

HCID 43218479HCID 43218479, 화합물

HCID 178501943HCID 178501943, 화합물

생성물 1

HCID 20300160HCID 20300160, 화합물수율 90%

반응 조건

온도: 0 °C

실험 절차

23.8 Parts of 3-(benzoylmethylthio)-propionic acid methyl ester are added in the course of 30 minutes to 36 parts of a 30 percent strength by weight NaOCH3 /MeOH solution which has been cooled to 0° C., and the mixture is stirred for 2 hours at from 0° to 10° C. The end product is isolated from the reaction mixture by the method described in Example 14b). 18.5 parts (90% of theory) of 3-hydroxy-2-benzoyldihydrothiophene of boiling point 137°-140° C./0.16-0.08 mbar are obtained.

후처리

customThe end product is isolated from the reaction mixture by the method

출처 및 근거

ORD 기록: ord-c10b345b49d54752acab38b36bc95d99
출처 데이터셋: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04239897

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