Bromine → HCID 20303432, 화합물

HRID 1732996노트

반응식

HRID 1732996 반응식
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Br:16]Br>C(Cl)(Cl)(Cl)Cl>[Br:16][C:4]1[CH:3]=[N:2][N:1]([C:6]2[CH:7]=[CH:8][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][CH:11]=2)[CH:5]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 12094244[4-(1H-Pyrazol-1-yl)phenyl]acetic acid

생성물 1

HCID 20303432HCID 20303432, 화합물수율 98%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매2회

실험 절차

20.2 g (100 mmoles) of 4-(pyrazol-1-yl)phenylacetic acid are dissolved in 400 ml of carbon tetrachloride. 16 g of bromine (200 mmoles) in 400 ml of carbon tetrachloride are added dropwise, with ice cooling, to the resulting solution. After subsequent stirring for half an hour at room temperature, washing with sodium dithionite solution is effected; this is followed by drying with sodium sulfate and, finally, by evaporation to dryness to obtain 27.5 g (98% of theory) of 4-(4-bromo-pyrazol-1-yl)phenylacetic acid, m.p. 187° C. (from acetonitrile).

후처리

  1. washwashing with sodium dithionite solution
  2. dry with materialby drying with sodium sulfate
  3. customfinally, by evaporation to dryness

출처 및 근거

ORD 기록
ord-26a8ee40f231404b9ea6c16fc754a339
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239901

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