19-Hydroxy-6alpha-methyl-4-androstene-3,17-dione → 1beta-Methyl-19-triphenylsiloxy-4-androstene-3,17-dione

HRID 1733071

반응식

HRID 1733071 반응식
O[CH2:2][C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C(=O)CC4)C[C@H](C)C1=CC(=O)CC2.C[O-].[C:26]1([Si:32]([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[O:33][CH2:34][C@@:35]23[C@@H:52]4[C@H:43]([C@H:44]5[C@@:48]([CH2:50][CH2:51]4)([CH3:49])[C:47](=[O:53])[CH2:46][CH2:45]5)[CH2:42][CH2:41][C:40]2=[CH:39][C:38](=[O:54])[CH2:37][CH2:36]3)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH3:2][C@H:36]1[C@@:35]2([CH2:34][O:33][Si:32]([C:61]3[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=3)([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=3)[C:40]([CH2:41][CH2:42][C@@H:43]3[C@@H:52]2[CH2:51][CH2:50][C@@:48]2([CH3:49])[C@H:44]3[CH2:45][CH2:46][C:47]2=[O:53])=[CH:39][C:38](=[O:54])[CH2:37]1

참가 물질

3

반응물 2

HCID 7058392519-Hydroxy-6alpha-methyl-4-androstene-3,17-dioneHCID 8673567919-(Triphenylsiloxy)-4-androstene-3,17-dione methanolate

생성물 1

HCID 228032651beta-Methyl-19-triphenylsiloxy-4-androstene-3,17-dione

실험 절차

Following essentially the same procedure but substituting 19-hydroxhy-1β-methyl-4-androstene-3,17-dione and 19-hydroxy-6α-methyl-4-androstene-3,17-dione for the 19-hydroxy-4-androstene-3,17-dione above results in the preparation of 1β-methyl-19-triphenylsiloxy-4-androstene-3,17-dione and 6α-methyl-19-triphenylsilioxy-4-androstene-3,17-dione.

출처 및 근거

ORD 기록
ord-92dc09a3029d4cd5b7d6bda769053cc5
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239681

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