Sodium Bicarbonate → 1alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

HRID 1733092노트

반응식

HRID 1733092 반응식
[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][O:22]C(=O)CC)[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+]>CO>[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][OH:22])[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 705838891alpha-Methyl-4-androstene-17beta,19-diol dipropionate

생성물 1

HCID 705847651alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 1α-methyl-4-androstene-17β,19-diol dipropionate in 10% aqueous methanol is added 1 equivalent sodium bicarbonate and the solution is heated under reflux for one hour. Methanol is removed under vacuum to half volume and the concentrate is poured onto water. The solid is filtered, air dried and crystallized from hexane to give 1α-methyl-4-androstene-17β,19-diol 17-propionate.

후처리

  1. temperaturethe solution is heated
  2. temperatureunder reflux for one hour
  3. customMethanol is removed under vacuum to half volume
  4. additionthe concentrate is poured onto water
  5. filtrationThe solid is filtered
  6. customair dried
  7. customcrystallized from hexane

출처 및 근거

ORD 기록
ord-469939cb380142c0b0011e13d7ed5b35
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239681

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