Thionyl Chloride → 2-Bromo-3,3,3-trifluoropropanoyl chloride

반응식

[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3](O)=[O:4].S(Cl)([Cl:12])=O>>[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3]([Cl:12])=[O:4]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 136803062-Bromo-3,3,3-trifluoropropanoic acid

생성물 1

HCID 540458592-Bromo-3,3,3-trifluoropropanoyl chloride

실험 절차

A solution of 2-bromo-3,3,3-trifluoropropanoic acid (5 g.) in thionyl chloride (5 ml.) is refluxed in the steam bath for two hours. The excess thionyl chloride is removed in vacuo, and the residue distilled under reduced pressure to yield 2-bromo-3,3,3-trifluoropropanoic acid chloride.

후처리

customThe excess thionyl chloride is removed in vacuo
distillationthe residue distilled under reduced pressure

출처 및 근거

ORD 기록: ord-17e0cc6d16604f04b024430f25787f22
출처 데이터셋: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04241076

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