Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Toluenesulfonyl chloride → cis-N-Carbobenzyloxy-4-tosyloxy-L-proline, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | (2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 688413 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | cis-N-Carbobenzyloxy-4-tosyloxy-L-proline, methyl ester | HCID 14036189 | — |
반응 단계
Following the procedure of Example 19(b), the methyl ester product from part (b) is treated with 12.4 g. of tosyl chloride in 45 ml. of pyridine to give 13.2 g. of cream-colored product; m.p. 114°-117° (s. 105°). 13 g. of this material are recrystallized from 70 ml. of ethanol to 8.4 g. of colorless cis-N-carbobenzyloxy-4-tosyloxy-L-proline, methyl ester; m.p. 133°-135°; [α]D25 -26° (c=1%, chloroform).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04241076 |
| 출처 데이터셋 | uspto-grants-1980_12 |
| ORD ID | ord-291d7a927ed04c2781925f8e6d809f78 |
| 출처 메모 | uspto-grants-1980_12 |