HCID 178508524, 화합물 → HCID 178460095, 화합물

HRID 1733360노트

반응식

HRID 1733360 반응식
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>C(OC(=O)CC)(=O)CC>[NH2:9][C:5]1[C:6]([OH:8])=[N:7][C:2]([NH:1][C:6](=[O:8])[CH2:5][CH3:4])=[N:3][CH:4]=1

참가 물질

3

반응물 1

HCID 178508524HCID 178508524, 화합물

생성물 1

HCID 178460095HCID 178460095, 화합물

시약·촉매·용매 1

HCID 31263Propionic anhydride용매

실험 절차

7.8 gm (0.055 mol) of 2-amino-4-hydroxy-5-nitropyrimidine are heated for 4 hours to 140° C. in 50 ml of propionic acid anhydride. The mixture is cooled and the precipitated product is extracted and washed with ether. The compound is suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature and normal pressure with 1 gm of Pd/C as catalyst.

후처리

  1. temperatureThe mixture is cooled
  2. extractionthe precipitated product is extracted
  3. washwashed with ether
  4. customis suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature

출처 및 근거

ORD 기록
ord-6780981f04054bb19670ac98233bcbaf
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04241056

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