Piperazine → HCID 12841593, 화합물

HRID 1733464노트

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HRID 1733464 반응식
[Cl:1]C1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=NC=1.Br[C:13]1[C:14]2[N:15]([C:19]([Cl:22])=[CH:20][N:21]=2)[CH:16]=[CH:17][N:18]=1.N1CCNCC1>C(#N)C>[ClH:1].[Cl:22][C:19]1[N:15]2[CH:16]=[CH:17][N:18]=[C:13]([N:6]3[CH2:7][CH2:8][NH:9][CH2:10][CH2:5]3)[C:14]2=[N:21][CH:20]=1

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 12841587HCID 12841587, 화합물HCID 202996378-Bromo-3-chloroimidazo[1,2-a]pyrazine

생성물 1

HCID 12841593HCID 12841593, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of the mixture of 3,8-dichloroimidazo[1,2-a]pyrazine and 8-bromo-3-chloroimidazo[1,2-a]pyrazine obtained above in 25 ml of acetonitrile is added an excess amount of piperazine (5 g). After refluxing and isolation in essentially the same manner as Example 1, Step B, 3-chloro-8-(1-piperazinyl)-imidazo[1,2-a]pyrazine hydrochloride salt is obtained with m.p. >300° C. dec.

후처리

  1. temperatureAfter refluxing

출처 및 근거

ORD 기록
ord-9399a5c83c834b4dbc2ba942bd37d36b
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242344

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