Propargylamine → 6-Chloro-5-(2-propyn-1-ylamino)-2-pyrazinecarboxylic acid

HRID 1733467노트

반응식

HRID 1733467 반응식
Cl[C:2]1[C:7]([Cl:8])=[N:6][C:5]([C:9]([OH:11])=[O:10])=[CH:4][N:3]=1.[NH2:12][CH2:13][C:14]#[CH:15]>O1CCOCC1>[Cl:8][C:7]1[C:2]([NH:12][CH2:13][C:14]#[CH:15])=[N:3][CH:4]=[C:5]([C:9]([OH:11])=[O:10])[N:6]=1

참가 물질

4

반응물 2

HCID 239041PropargylamineHCID 202996445,6-Dichloropyrazine-2-carboxylic acid

생성물 1

HCID 202996246-Chloro-5-(2-propyn-1-ylamino)-2-pyrazinecarboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2,3-dichloropyrazine-5-carboxylic acid (19.3 g, 0.100 mole) and 3-amino-1-propyne (1.10 g, 0.20 mole) in 100 ml dioxane is refluxed for 24 hours, cooled and concentrated under vacuum. The residue is partitioned between aqueous sodium bicarbonate and chloroform and the aqueous extract neutralized with acetic acid to give a precipitate of 3-chloro-2-(2-propyn-1-ylamino)pyrazine-5-carboxylic acid.

후처리

  1. temperatureis refluxed for 24 hours
  2. temperaturecooled
  3. concentrationconcentrated under vacuum
  4. customThe residue is partitioned between aqueous sodium bicarbonate and chloroform
  5. extractionthe aqueous extract

출처 및 근거

ORD 기록
ord-21e9929954bc4d0b8f2691a5f480b50c
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242344

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