Potassium Hydroxide → 2-Isoxazolidinecarboxylic acid, ethyl ester

반응식

C(Br)CCBr.[C:6]([N:11]1[CH2:15][CH2:14][CH2:13][O:12]1)([O:8][CH2:9][CH3:10])=[O:7].[OH-].[K+]>>[C:6]([N:11]1[CH2:15][CH2:14][CH2:13][O:12]1)([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 20299603HCID 20299603, 화합물

생성물 1

HCID 5336912-Isoxazolidinecarboxylic acid, ethyl ester

실험 절차

N-Carbethoxyisooxazolidine Trimethylene dibromide (40.4 g; 0.4 mole) and an ethanolic solution (224 ml.) containing potassium hydroxide (22.4 g; 0.4 mole) are boiled together on a steam bath for six hours. The ethanol is removed by distillation and the residue triturated with ether (3×100 ml.). The combined ether washes are dried over anhydrous magnesium sulfate, filtered and concentrated to give a liquid which is vacuum distilled to give N-carbethoxyisooxazolidine, b.p. 103° C./13 mm.

후처리

customThe ethanol is removed by distillation
customthe residue triturated with ether (3×100 ml.)
dry with materialThe combined ether washes are dried over anhydrous magnesium sulfate
filtrationfiltered
concentrationconcentrated
customto give a liquid which
distillationdistilled

출처 및 근거

ORD 기록: ord-b5f15fb4790c4a21a4f9eee9a6454e41
출처 데이터셋: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04242338

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