O-methylhydroxylammonium chloride → 1-Benzyl-4-methoxyiminopiperidine

HRID 1733480

반응식

HRID 1733480 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:16][O:17][NH3+:18]>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[N:18][O:17][CH3:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 11639O-methylhydroxylammonium chlorideHCID 192201-Benzyl-4-piperidone

생성물 1

HCID 119596661-Benzyl-4-methoxyiminopiperidine

실험 절차

The starting material is prepared as follows: The solution of 94.5 g of 1-benzyl-4-piperidone and 46 g of methoxyammonium chloride in 600 ml of ethanol-pyridine (1:1) is refluxed overnight and evaporated. The residue is dissolved in water, the solution made basic with 12.5% aqueous sodium hydroxide and extracted with diethyl ether. The extract is washed with water and saturated aqueous sodium hydroxide, dried and evaporated, to yield the 1-benzyl-4-methoxyiminopiperidine.

후처리

  1. customThe starting material is prepared
  2. customevaporated
  3. dissolutionThe residue is dissolved in water
  4. extractionextracted with diethyl ether
  5. washThe extract is washed with water and saturated aqueous sodium hydroxide
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-e731adbf9a984c4aac164a4561121550
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242347

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