Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Ethyl N-(1-((benzyloxy)carbonyl)-L-prolyl)-L-leucinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
| 반응물 | L-Leucine, ethyl ester, hydrochloride (1:1) | HCID 11658447 | — |
| 반응물 | 4-Oxo-3,4-dihydro-3-methanesulfonyloxy-1,2,3-benzotriazine | HCID 21896281 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl N-(1-((benzyloxy)carbonyl)-L-prolyl)-L-leucinate | HCID 6453075 | 66.4% |
반응 단계
N-Benzyloxycarbonyl-L-proline (1.25 g), L-leucine ethyl ester hydrochloride (1.00 g) and N-methylmorpholine (1.10 ml) are dissolved in chloroform (10 ml) and thereto is added 4-oxo-3,4-dihydro-3-methanesulfonyloxy-1,2,3-benzotriazine (1.20 g). After allowing to stand overnight, to the mixture are added water and ethyl acetate. The ethyl acetate layer is washed and dried, and then the solvent is distilled off to give N-(N-benzyloxycarbonyl-L-prolyl)-L-leucine ethyl ester (1.3 g), melting point: 65°-67° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04242507 |
| 출처 데이터셋 | uspto-grants-1980_12 |
| ORD ID | ord-89cf0924f3e74005978288a0de1fd424 |
| 출처 메모 | uspto-grants-1980_12 |