N-Boc-O-benzylserine hydroxysuccinimide → Methyl o-benzyl-n-(tert-butoxycarbonyl)serinate

HRID 1733773노트

반응식

HRID 1733773 반응식
[C:1]([NH:8][C@H:9]([C:19]([OH:21])=[O:20])[CH2:10][O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].O[CH:23]1CC(=O)NC1=O>CO>[CH3:23][O:20][C:19](=[O:21])[C@H:9]([CH2:10][O:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[NH:8][C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

3

반응물 1

HCID 67731037N-Boc-O-benzylserine hydroxysuccinimide

생성물 1

HCID 14427182Methyl o-benzyl-n-(tert-butoxycarbonyl)serinate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

N-Boc-O-benzylserine-hydroxysuccinimide (16.0 g, 40.8 mmol) was dissolved in methanol (300 ml) and stirred at 50° C. for 24 hours. The solvent was evaporated and the residue was taken up in ethyl acetate (120 ml), washed with aqueous saturated sodium bicarbonate (2×50 ml) and water (50 ml). The organic solution was dried with sodium sulphate and after evaporation of the solvent the N-Boc-O-benzylserine methyl ester was isolated as a colourless oil. Yield 9.9 g (83%). The structure was confirmed by 1HNMR and 13CNMR.

후처리

  1. customThe solvent was evaporated
  2. washwashed with aqueous saturated sodium bicarbonate (2×50 ml) and water (50 ml)
  3. dry with materialThe organic solution was dried with sodium sulphate
  4. customafter evaporation of the solvent the N-Boc-O-benzylserine methyl ester
  5. customwas isolated as a colourless oil

출처 및 근거

ORD 기록
ord-a17e7192fa664ea8a4548c823f85da6c
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05531978

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