Ethyl 4-bromobutyrate → 2,3-Dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)-1H-indole-3-butanoic Acid Ethyl Ester

HRID 1733929

반응식

HRID 1733929 반응식
[O:1]=[C:2]1[CH:10]([CH2:11][C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Br[CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[CH2:31]([O:30][C:28](=[O:29])[CH2:27][CH2:26][CH2:25][C:10]1([CH2:11][C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:2]1=[O:1])[CH3:32]

참가 물질

3

반응물 2

HCID 76300Ethyl 4-bromobutyrateHCID 194389852,3-dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)1H-indole

생성물 1

HCID 537431992,3-Dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)-1H-indole-3-butanoic Acid Ethyl Ester수율 80%

실험 절차

By substituting 2,3-dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)-1H-indole and ethyl 4-bromobutyrate in Example 1, the desired product was obtained in 80% yield as an oil.

출처 및 근거

ORD 기록
ord-6e9ca825f47e4cf38b7511be7d953f09
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532247

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