1-[3-(Chloromethyl)-4-methoxyphenyl]ethan-1-one → HCID 3922617, 화합물

HRID 1734020노트

반응식

HRID 1734020 반응식
Cl[CH2:2][C:3]1[CH:4]=[C:5]([C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C)C=O>[C:14]1(=[O:24])[N:18]([CH2:2][C:3]2[CH:4]=[C:5]([C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][C:8]=2[O:9][CH3:10])[C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12

참가 물질

4

반응물 2

HCID 27767231-[3-(Chloromethyl)-4-methoxyphenyl]ethan-1-oneHCID 24194345Phthalimide potassium salt

생성물 1

HCID 3922617HCID 3922617, 화합물수율 76.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A solution of 3'-chloromethyl-4'-methoxyacetophenone (10.0 g) in N,N-dimethylformamide (30 ml) was added slowly to a suspension of potassium phthalimide (9.4 g) in N,N-dimethylformamide (70 ml) at room temperature and then the mixture was stirred for 9 hours at room temperature. After removed of the insoluble material, the solvent was removed under reduced pressure. The residue was suspended in water (100 ml). The mixture was extracted with ethyl acetate (300 ml). The extract was dried with magnesium sulfate. The solvent was removed under reduced pressure to afford 3'-phthalimidomethyl-4'-methoxyacetophenone (11.94 g).

후처리

  1. customAfter removed of the insoluble material
  2. customthe solvent was removed under reduced pressure
  3. extractionThe mixture was extracted with ethyl acetate (300 ml)
  4. dry with materialThe extract was dried with magnesium sulfate
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-b53026b57b1a4e2990d3755a75831a4c
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532258

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