4-(Bis(4-fluorophenyl)methylene)piperidine → 2-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

HRID 1734050노트

반응식

HRID 1734050 반응식
C([N:4]1[CH2:9][CH2:8][C:7]2[C:10](CCCl)=[C:11]([CH3:13])[S:12][C:6]=2[CH2:5]1)(=O)C.FC1C=CC(C(C2C=CC(F)=CC=2)=C2CCNCC2)=CC=1>>[CH3:13][C:11]1[S:12][C:6]2[CH2:5][NH:4][CH2:9][CH2:8][C:7]=2[CH:10]=1

참가 물질

3

반응물 2

HCID 27244364-(Bis(4-fluorophenyl)methylene)piperidineHCID 214718566-Acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine

생성물 1

HCID 144231542-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

실험 절차

The reaction and procedure were conducted in a similar manner as in Example 24 using 0.7 g of 6-acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine and 0.6 g of 4-(bis(4-fluorophenyl)-methylene)piperidine to give 0.5 g of 6-acetyl-3-(2-(4-bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine as an oil, m.p. 209°-211° C. as axalate thereof.

후처리

  1. customThe reaction and procedure

출처 및 근거

ORD 기록
ord-68b614ca92894a85b978322c3b4e2023
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532240

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