Potassium Carbonate → 2-Amino-3-cyano-5-ethynylpyrazine

HRID 1734158노트

반응식

HRID 1734158 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[C:11][Si](C)(C)C)=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[CH:11])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 153352712-Amino-3-cyano-5-(trimethylsilylethynyl)pyrazine

생성물 1

HCID 153352732-Amino-3-cyano-5-ethynylpyrazine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.3 grams (0.006 mole) of 2-amino-3-cyano-5-(trimethylsilylethynyl)pyrazine and 0.9 gram (0.006 mole) of potassium carbonate in 50 mL of methanol is stirred at ambient temperature for one hour. The reaction mixture is then concentrated under reduced pressure to a residue. The residue is taken up in about 75 mL of water, and the solution is extracted with two 200 mL portions of ethyl acetate. The combined extracts are dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 2-amino-3-cyano-5-ethynylpyrazine. This reaction is repeated several times.

후처리

  1. concentrationThe reaction mixture is then concentrated under reduced pressure to a residue
  2. extractionthe solution is extracted with two 200 mL portions of ethyl acetate
  3. dry with materialThe combined extracts are dried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0218a5db79164e56b56aca4c92d3bbc1
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532367

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