Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → RO-05-2921
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-(2-Benzoylphenyl)-2-bromoacetamide | HCID 84439 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | RO-05-2921 | HCID 76175 | 98% |
반응 단계
A suspension of 2-bromoacetamidobenzophenone (275 g, 0.86 mol) in methanol (1 L) was treated with a solution of saturated ammonia in methanol (3 L), and the resulting solution was stirred at ambient temperature for 6 h, then was heated at reflux for an additional 4 h. After cooling, water (500 mL) was added, and the solution was concentrated by evaporation to about 1 L in volume, yielding crystalline 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (20) (200.7 g, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05532359 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-a0826e8108a34c36a4b1e6d5676bbd6a |
| 출처 메모 | uspto-grants-1996_07 |