Diethyl Ether → HCID 54320917, 화합물

HRID 1734428노트

반응식

HRID 1734428 반응식
C1(=O)N(N([C:11](=[O:22])[CH2:12][S:13][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)CC([O-])=O)C(=O)CC1.[NH2:25][C@@H:26]([C:28]([NH:30][CH2:31][C:32]([NH:34][CH2:35][C:36]([OH:38])=[O:37])=[O:33])=[O:29])[CH3:27].C(OCC)C>C(O)C.O>[C:14]([S:13][CH2:12][C:11]([NH:25][C@@H:26]([C:28]([NH:30][CH2:31][C:32]([NH:34][CH2:35][C:36]([OH:38])=[O:37])=[O:33])=[O:29])[CH3:27])=[O:22])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 154942777286-90-9HCID 86743235HCID 86743235, 화합물

생성물 1

HCID 54320917HCID 54320917, 화합물수율 47%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 1 g of succinimidyl-N-(S-benzoylmercaptoacetyl)glycinate in 25 ml of anhydrous ethanol at 70° C. is added in one portion a solution of 203 mg of D-alanylglycylglycine in 10 ml of water at 70° C. The reaction mixture is refluxed for 1 hour and the solvents are evaporated under reduced pressure. The residue is agitated with 5 portions of 25 ml acetone, which is isolated by filtration. The combined filtrates are treated with diethylether until precipitation is complete. The precipitate is filtered off, washed with diethylether and dried over P2O5 under vacuum to obtain 170 mg (47,7%) of S-benzoylmercaptoacetyl-D-alanylglycylglycine as a white powder, m.p. 167°-170° C.

후처리

  1. temperatureThe reaction mixture is refluxed for 1 hour
  2. customthe solvents are evaporated under reduced pressure
  3. customwhich is isolated by filtration
  4. filtrationThe precipitate is filtered off
  5. washwashed with diethylether
  6. dry with materialdried over P2O5 under vacuum

출처 및 근거

ORD 기록
ord-0e4a21109a4c4495a27166b3877ad776
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05534497

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