1,3,8-Triazaspiro(4.5)decane-2,4-dione, 8-methyl- → 4-Amino-1-methylpiperidine-4-carboxylic acid
반응식
[CH3:1][N:2]1[CH2:13][CH2:12][C:5]2([NH:9]C(=O)N[C:6]2=[O:11])[CH2:4][CH2:3]1.[OH2:14].O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O>[NH2:9][C:5]1([C:6]([OH:11])=[O:14])[CH2:4][CH2:3][N:2]([CH3:1])[CH2:13][CH2:12]1참가 물질
4
실험 절차
1-Methylpiperidine-4-spiro-5'-hydantoin (9.75 g, 0.0533 mole) and barium hydroxide octahydrate (28.8 g, 0.0913 mole) in water (150 ml) were heated at 160° C. in a bomb for 3 hr. The content of four such batches were combined and the precipitated barium carbonate was filtered off. The filtrate was neutralized with solid CO2 and the precipitate removed by filtration. The filtrate was concentrated to give 4-amino-1-methylpiperidine-4-carboxylic acid (32.0 g., 95%) mp. 275°-280° C. (dec.).
후처리
- filtrationthe precipitated barium carbonate was filtered off
- customthe precipitate removed by filtration
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-8ca3b7d6988948eaa0d60a00f9163b9b
- 출처 데이터셋
- uspto-grants-1996_07
- 특허 번호
- US05534520
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