Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-6-methylbenzonitrile → Quinazoline, 2,4-diamino-5-methyl-(7CI,8CI)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-6-methylbenzonitrile | HCID 279973 | — |
| 반응물 | Chloroformamidinium chloride | HCID 3084509 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 생성물 | Quinazoline, 2,4-diamino-5-methyl-(7CI,8CI) | HCID 198062 | 86.9% |
반응 단계
This compound was prepared in a manner analogous to that of Step E of Example 1, using 10.0 grams (0.076 mole) of 2-amino-6-methylbenzonitrile (prepared as in Example 1, Step B), and 10.0 grams (0.087 mole) of chloroformamidine hydrochloride in 40 mL of 2-methoxyethyl ether, yielding 11.5 grams of 2,4-diamino-5-methylquinazoline. The NMR spectrum was consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05534518 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-2b2a890cd01b4ee9ac25ab096046fc03 |
| 출처 메모 | uspto-grants-1996_07 |