Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylcyclohexanol → 1-Phenylcyclohexene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylcyclohexanol | HCID 15319 | — |
| 반응물 | Deuterium Oxide | HCID 24602 | — |
| 반응물 | 4-Bromophenetole | HCID 68523 | — |
| 반응물 | 4-Propylcyclohexanone | HCID 142482 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Phenylcyclohexene | HCID 13043 | — |
반응 단계
4-Propylcyclohexanone is dissolved in a solvent, e.g., dichloromethane, and heated with heavy water (D2O) in the presence of a base to obtain 4-propylcyclohexanone-2,2,6,6-d4, which is then reacted with a Grignard reagent prepared from 1-ethoxy-4-bromobenzene. The resulting d4 -phenylcyclohexanol derivative is dehydrated to obtain a d3 -phenylcyclohexene derivative. The d3 -phenylcyclohexene derivative is catalytically reduced, and the cis-compound is removed to obtain 1-(trans-4-propylcyclohexyl-2,2,6-d3)-4-ethoxybenzene. ##STR60##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05536443 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-693aac6a46134b7f9e10d39df891da98 |
| 출처 메모 | uspto-grants-1996_07 |