1-Bromo-4-(trifluoromethoxy)benzene → 2-(4'-Trifluoromethoxybiphenyl-4-yl)-5-propylpyrimidine

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([CH2:14][CH2:15][CH3:16])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[F:17][C:18]([F:28])([F:27])[O:19][C:20]1[CH:25]=[CH:24][C:23](Br)=[CH:22][CH:21]=1>>[F:17][C:18]([F:27])([F:28])[O:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[N:13]=[CH:12][C:11]([CH2:14][CH2:15][CH3:16])=[CH:10][N:9]=3)=[CH:4][CH:3]=2)=[CH:22][CH:21]=1

참가 물질

반응물 2

HCID 5210081-Bromo-4-(trifluoromethoxy)benzene

HCID 136514502-(4-Bromophenyl)-5-propylpyrimidine

생성물 1

HCID 144384522-(4'-Trifluoromethoxybiphenyl-4-yl)-5-propylpyrimidine

실험 절차

Analogously to Example 9 , by reacting 14.0 g of 2-(4-bromophenyl)-5-propylpyrimidine and 12.1 g of trifluoromethoxy-4-bromobenzene, the corresponding 2-(4'-trifluoromethoxybiphenyl-4-yl )-5-propylpyrimidine having C 125° SG 1110 SA 218° I is obtained.

출처 및 근거

ORD 기록: ord-0504ded8d53b4732a31ae4d77bf4ef0f
출처 데이터셋: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05536442

반응 노트

불러오는 중…