Water → HCID 10459854, 화합물

HRID 1735496노트

반응식

HRID 1735496 반응식
[CH:1]1[CH:6]=[C:5]([OH:7])[C:4]2[NH:8][C:9]3[C:14]([C:3]=2[CH:2]=1)=[C:13]1[C:15]([NH:17][C:18](=[O:19])[C:12]1=[C:11]1[C:20]2[CH:26]=[CH:25][CH:24]=[C:23]([OH:27])[C:21]=2[NH:22][C:10]=31)=[O:16].C(=O)([O-])[O-].[K+].[K+].[CH2:34](Br)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.O>CN(C)C=O>[CH2:34]([O:27][C:23]1[C:21]2[NH:22][C:10]3[C:9]4[NH:8][C:4]5[C:3](=[CH:2][CH:1]=[CH:6][C:5]=5[O:7][CH2:14][C:3]5[CH:4]=[CH:5][CH:6]=[CH:1][CH:2]=5)[C:14]=4[C:13]4[C:15](=[O:16])[NH:17][C:18](=[O:19])[C:12]=4[C:11]=3[C:20]=2[CH:26]=[CH:25][CH:24]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 9928668BE 13793C

생성물 1

HCID 10459854HCID 10459854, 화합물수율 93.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

180.5 mg of BE-13793C (12,13-dihydro-1,11-dihydroxy-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-(6H)-dione) was dissolved in 137 ml of N,N-dimethylformamide (DMF), 510 mg of potassium carbonate was added, and 170 μl of benzyl bromide was added under ice cooling. The reaction solution was stirred at room temperature for 2 hours and, after addition of 200 ml of water, extracted with 200 ml of ethyl acetate, and the extract was dried over sodium sulfate and concentrated under reduced pressure to give 1,11-dibenzyloxy-12,13-dihydro-5H-indolo[ 2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (yield: 93.7%).

후처리

  1. extractionextracted with 200 ml of ethyl acetate
  2. dry with materialthe extract was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-de5740a93a9548fc8647806fd5ab127e
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05536827

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