Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pamoic Acid → Octreotide pamoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pamoic Acid | HCID 8546 | — |
| 반응물 | Octreotide | HCID 448601 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | Octreotide pamoate | HCID 44194024 | — |
반응 단계
10.19 g of octreotide free base (10 mM) and 3.88 embonic acid (10 mM) are dissolved in 1 liter of water/dioxane (1:1). The reaction mixture is filtered, and lyophilized to give a yellow powder [α]20D=+7.5° (C=0.35, in DMF), of octreotide pamoate hydrate. Factor=1.4 wherein the factor=weight of lyophilizate/weight of octreotide contained therein.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05538739 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-b47e8b278e13464894097467ad20f6c6 |
| 출처 메모 | uspto-grants-1996_07 |