Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Dimethylaminopyridine → Morpholine-4-carboxylic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(3-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 4-Morpholinecarbonyl chloride | HCID 84810 | — |
| 반응물 | Ro 46-2005 | HCID 122044 | — |
| 생성물 | Morpholine-4-carboxylic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(3-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester | HCID 54072965 | — |
반응 단계
In analogy to Example 1, part a), from 0.15 ml of morpholine-4-carbonyl chloride and 200 mg of p-tert-butyl-N-[6-(2-hydroxy-ethoxy) -5-(m-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide with the addition of 154 mg of dimethylaminopyridine at a reaction period of 12 hours there was obtained morpholine-4-carboxylic acid 2-[6-(4-tert -butyl-phenylsulfonylamino)-5-(3-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester. MS: 587.4 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05541186 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-b54aaf3a09f043688c195c0eb7a46914 |
| 출처 메모 | uspto-grants-1996_07 |