Cyclopentylhydrazine hydrochloride → 1-cyclopentyl-3-phenylmethyl-4-cyano-5-amino-1H-pyrazole

HRID 1736555

반응식

HRID 1736555 반응식
Cl.[CH:2]1([NH:7][NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C[O-].[Na+].CO[C:14]1([CH2:20][CH:21]=[C:22]([C:25]#[N:26])[C:23]#[N:24])[CH:19]=[CH:18][CH:17]=[CH:16][CH2:15]1>C(O)C>[CH:2]1([N:7]2[C:25]([NH2:26])=[C:22]([C:23]#[N:24])[C:21]([CH2:20][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 212349Cyclopentylhydrazine hydrochlorideHCID 10942334Sodium MethoxideHCID 86747657(1-Methoxyphenylethylidene)malononitrile

생성물 1

HCID 218309241-cyclopentyl-3-phenylmethyl-4-cyano-5-amino-1H-pyrazole수율 26%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A mixture of cyclopentyl hydrazine hydrochloride (1.4 g, 10.2 mmol), sodium methoxide (0.55 g, 10.2 mmol) and ethanol (30 ml) was heated to reflux and then (1-methoxyphenylethylidene)malononitrile (2.0 g, 10.2 mmol) in ethanol (15 ml) was added dropwise over 1 hour. The reaction mixture was refluxed for 6.5 hours and the solvent was removed in vacuo. The residue was partitioned between chloroform and water, the organic layer was separated and the aqueous layer was extracted with chloroform (3×75 ml). The combined organic layers were washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo to afford 0.7 g (26%) of 1-cyclopentyl-3-phenylmethyl-5-amino-1H-pyrazole-4-carbonitrile as white flakes, m.p. 180°-182° C. when recrystallized from ethyl acetate and dried for 18 hours at 90° C. in high vacuum.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureThe reaction mixture was refluxed for 6.5 hours
  4. customthe solvent was removed in vacuo
  5. customThe residue was partitioned between chloroform and water
  6. customthe organic layer was separated
  7. extractionthe aqueous layer was extracted with chloroform (3×75 ml)
  8. washThe combined organic layers were washed with brine
  9. dry with materialdried over anhydrous MgSO4
  10. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-162bb1cec3ac403caa1b9a7b7b3b9023
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05541187

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