Morpholine → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

HRID 1736597노트

반응식

HRID 1736597 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 5686382-Chloro-4-cyanopyridine

생성물 1

HCID 146408562-(Morpholin-4-yl)pyridine-4-carbonitrile수율 53%

실험 절차

A mixture of 2-chloro-4-cyanopyridine (2.5 g, 18 mmol) and morpholine (6.29 g, 72 mmol) was heated at 110°-120° C. for 4 hours. The reaction mixture was cooled, poured into ice-water (15 ml) and stirred for 30 minutes. A yellow solid was obtained, which was collected by filtration, washed with water and dried in vacuo at 70° C. in the presence of P2O5 to afford 1.8 g (53%) of 2-(4-morpholinyl)-4-cyanopyridine, m.p. 135°-136.5° C.

후처리

  1. temperaturewas heated at 110°-120° C. for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. customA yellow solid was obtained
  4. filtrationwhich was collected by filtration
  5. washwashed with water
  6. dry with materialdried in vacuo at 70° C. in the presence of P2O5

출처 및 근거

ORD 기록
ord-5f0feb342a70407baf953be5a6d37ce9
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05541187

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