Thionyl Chloride → 6-Cyanonaphthalene-2-carbonyl chloride

HRID 1737070노트

반응식

HRID 1737070 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](O)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:14]([NH2:16])=O.S(Cl)([Cl:19])=O>CN(C)C=O>[C:14]([C:2]1[CH:1]=[C:10]2[C:5](=[CH:4][CH:3]=1)[CH:6]=[C:7]([C:11]([Cl:19])=[O:12])[CH:8]=[CH:9]2)#[N:16]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 211863766-(Aminocarbonyl)-2-naphthalenecarboxylic acid

생성물 1

HCID 124330916-Cyanonaphthalene-2-carbonyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

2.8 g of naphthalene-2,6-dicarboxylic acid monoamide, 10 ml of thionylchloride and 1 drop of dimethylformamide are refluxed for 5 hours. The clear yellow solution is evaporated down in vacuo and the solid evaporation residue is mixed with 20 ml of diethylether and 20 ml of petroleum ether, then stirred and suction filtered. The filter cake is washed with petroleum ether and diethylether and dried in vacuo.

후처리

  1. customThe clear yellow solution is evaporated down in vacuo
  2. customthe solid evaporation residue
  3. additionis mixed with 20 ml of diethylether and 20 ml of petroleum ether
  4. filtrationsuction filtered
  5. washThe filter cake is washed with petroleum ether and diethylether
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-106617a06650425380cd019f87b3d912
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05541343

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