Pivaloyl chloride → HCID 22611644, 화합물

반응식

C([O-])C.Cl.Cl.[NH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1.[CH3:23][C:24]([CH3:29])([CH3:28])[C:25](Cl)=[O:26]>>[CH3:23][C:24]([CH3:29])([CH3:28])[C:25]([NH:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)=[O:26]

참가 물질

반응물 2

HCID 62493Pivaloyl chloride

HCID 86751892HCID 86751892, 화합물

생성물 1

HCID 22611644HCID 22611644, 화합물수율 34.6%

실험 절차

Beginning with 2.00 gm (5.74 mMol) 5-amino-3-(1-methyl-piperidin-4-yl)-1H-indole dihydrochloride ethanolate and 1.78 gm (14.4 mMol) trimethylacetyl chloride, 0.623 gm (34.6%) of the title compound were recovered as an off-white powder.

출처 및 근거

ORD 기록: ord-91874ff711e04dca8926ccbdaaf0ba0b
출처 데이터셋: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05962474

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