4-(Imidazol-1-ylmethyl)benzonitrile → 1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole

HRID 1737867노트

반응식

HRID 1737867 반응식
[C:1]([C:3]1[CH:14]=[CH:13][C:6]([CH2:7][N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH:23]=[O:24])=[CH:18][CH:17]=1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:7]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[CH:23]([OH:24])[CH2:22][C:19]2[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=2)=[CH:13][CH:14]=1)#[N:2]

참가 물질

3

반응물 2

HCID 12364494-(Imidazol-1-ylmethyl)benzonitrileHCID 111263222-(4-fluorophenyl)acetaldehyde

생성물 1

HCID 218435811-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole

실험 절차

1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole is prepared according to the procedure of Example 1 using 1-(4-cyanobenzyl)-imidazole and 4-fluorophenylacetaldehyde as starting materials. The product is purified by flash chromatography.

후처리

  1. customThe product is purified by flash chromatography

출처 및 근거

ORD 기록
ord-cb0eae4244e0465f9dd3e78820af8ab0
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05962495

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