4-((2-Carboxy-2-(1,3-dithiol-2-ylidene)acetyl)amino)-5-(dipropylamino)-5-oxopentanoic acid → 5-(Dipropylamino)-4-((2-(1,3-dithiol-2-ylidene)acetyl)amino)-5-oxopentanoic acid
반응식
C([C:4](=[C:23]1[S:27][CH:26]=[CH:25][S:24]1)[C:5]([NH:7][CH:8]([C:14]([N:16]([CH2:20][CH2:21][CH3:22])[CH2:17][CH2:18][CH3:19])=[O:15])[CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:6])(O)=O>O1CCOCC1>[CH2:20]([N:16]([CH2:17][CH2:18][CH3:19])[C:14](=[O:15])[CH:8]([NH:7][C:5](=[O:6])[CH:4]=[C:23]1[S:27][CH:26]=[CH:25][S:24]1)[CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:21][CH3:22]참가 물질
3
반응 조건
- 온도
- 50 °C
실험 절차
Dioxane (1.5 l) and activated carbon (10 g) were added to the 4-((2-carboxy-2-(1,3-dithiol-2-ylidene)acetyl)amino)-5-(dipropylamino)-5-oxopentanoic acid (6) obtained in Synthesis Example 4. The resulting mixture was stirred at 50° C. for 30 minutes. The activated carbon was filtered off, and the solvent was removed from the filtrate under reduced pressure. Acetone was added to the thus-obtained residue. The resulting crystals were collected by filtration, washed with water, acetone and diethyl ether, and then dried at 60° C. for 8 hours under reduced pressure, whereby 5-(dipropylamino)-4-((2-(1,3-dithiol-2-ylidene)acetyl)amino)-5-oxopentanoic acid (1) (67 g, yield: 72% (based on the compound (5)) was obtained as pale yellow crystals.