Glycolic Acid → 3h-Imidazo[4,5-b]pyridine-2-methanol,3-methyl-5-(1-methylethoxy)-

HRID 1738277노트

반응식

HRID 1738277 반응식
[NH2:1][C:2]1[C:3]([NH:12][CH3:13])=[N:4][C:5]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][CH:7]=1.[C:14]([OH:18])(=O)[CH2:15]O>>[CH:9]([O:8][C:5]1[N:4]=[C:3]2[N:12]([CH3:13])[C:15]([CH2:14][OH:18])=[N:1][C:2]2=[CH:7][CH:6]=1)([CH3:11])[CH3:10]

참가 물질

3

반응물 2

HCID 757Glycolic AcidHCID 108212696-Isopropoxy-N2-methylpyridine-2,3-diamine

생성물 1

HCID 108228683h-Imidazo[4,5-b]pyridine-2-methanol,3-methyl-5-(1-methylethoxy)-수율 25%

실험 절차

A procedure similar to that described in Preparation 43 was repeated, except that 1.90 g of 3-amino-6-isopropoxy-2-methylaminopyridine (prepared as described in Preparation 101), and 2.39 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol, to give 0.58 g of the title compound, melting at 125-127° C.

후처리

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and methanol

출처 및 근거

ORD 기록
ord-dd0d757cf4094f1bb60baf2d8dd9a785
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05962470

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