2-Fluoro-2-trifluoromethyl-4-octenamide → 2-Fluoro-2-trifluoromethyloctanamide

HRID 1738737노트

반응식

HRID 1738737 반응식
[F:1][C:2]([C:12]([F:15])([F:14])[F:13])([CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH3:11])[C:3]([NH2:5])=[O:4].[H][H]>CO.[C].[Pd]>[F:1][C:2]([C:12]([F:13])([F:15])[F:14])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([NH2:5])=[O:4]

참가 물질

5

반응물 2

HCID 538353032-Fluoro-2-trifluoromethyl-4-octenamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 218389932-Fluoro-2-trifluoromethyloctanamide수율 76.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

Into a solution of 1.30 g of 2-fluoro-2-trifluoromethyl-4-octenamide in 13 ml of methanol, palladium-carbon (13 mg) was added under nitrogen. After the atmosphere was replaced with hydrogen, the mixture was stirred for 24 hours. To remove the catalyst, the resulting mixture was filtered with celite and the filtrate was concentrated. The raw product was purified by silica gel column chromatography to obtain 1.0 g of the desired compound.

후처리

  1. customTo remove the catalyst
  2. filtrationthe resulting mixture was filtered with celite
  3. concentrationthe filtrate was concentrated
  4. customThe raw product was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-ef76b54f5af44c2c907b8960f8b5f388
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965059

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