Sulfuric Acid → Succinanilic acid

HRID 1739631

반응식

HRID 1739631 반응식
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.S(=O)(=O)(O)O>C(#N)C>[C:10]1([NH:9][C:1](=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 6115AnilineHCID 138186494-Chloro-4-oxobutanoic acid

생성물 1

HCID 7598Succinanilic acid수율 63.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

100 mg of succinic acid monochloride are dissolved in 2 ml of anhydrous acetonitrile. 1.5 equivalents of aniline (102 mg) are added at room temperature and the reaction mixture is kept stirred for 30 minutes. 100 ml of 0.005M sulfuric acid are then added and the solution is extracted with ethyl ether (3×3 ml). The ether phases are combined and washed with water to neutrality and then dried over anhydrous MgSO4. The ether is then filtered and evaporated under reduced pressure to give 90 mg of N-phenylsuccinamic acid.

후처리

  1. extractionthe solution is extracted with ethyl ether (3×3 ml)
  2. washwashed with water to neutrality
  3. dry with materialdried over anhydrous MgSO4
  4. filtrationThe ether is then filtered
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3ad1ad6d4aa94b4482afbffd8cb89dd9
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05968794

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