Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(6-Aminohexyl)-1-naphthalenesulfonamide → Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(6-Aminohexyl)-1-naphthalenesulfonamide | HCID 4314 | — |
| 반응물 | 2-Chloroquinazolin-4-amine | HCID 252879 | — |
| 용매 | Isoamyl Alcohol | HCID 31260 | — |
| 생성물 | Naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]-amide | HCID 9955360 | — |
반응 단계
A solution of naphthalene-1-sulfonic acid (6-aminohexyl)-amide (0.450 g) and 2-chloro-quinazolin-4-ylamine (see: U.S. Pat. No. 3,956,495) (0.264 g) in 20 ml of isopentylalcohol is heated up to 120° C. for 15 h. Concentration of the reaction mixture followed by chromatography on silica gel (B1) yields naphthalene-1-sulfonic acid [6-(4-amino-quinazolin-2-ylamino)-hexyl]amide as a white powder, melting at 98-101° C. Rf(B1) 0.28, FAB-MS: (M+H)+ =450. Ananlytical C26H29N5O2S+HCl+H2O+0.6 1,4 dioxane. m.p. 98-101° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05968819 |
| 출처 데이터셋 | uspto-grants-1999_10 |
| ORD ID | ord-6e5d86a961db45ad87f908de3df2d89c |
| 출처 메모 | uspto-grants-1999_10 |