3,4,4-Trifluorobut-3-en-1-ol → 3,4,4-Trifluoro-3-butenoic acid
반응식
[F:1][C:2](=[C:6]([F:8])[F:7])[CH2:3][CH2:4][OH:5].CC(C)=[O:11].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[F:1][C:2](=[C:6]([F:8])[F:7])[CH2:3][C:4]([OH:11])=[O:5]참가 물질
4
실험 절차
The first method involves hydrolysis of 4-bromo-1,1,2-trifluoro-1-butene (II) with water in the presence of N-methyl pyrrolidinone to give 3,4,4-trifluoro-3-buten-1-ol (III), followed by Jones oxidation under conditions not previously known. These conditions are at a temperature of about 51-54° C. In addition, the 3,4,4-trifluoro-3-buten-1-ol in acetone solvent and the Jones reagent are added to the reaction vessel simultaneously to afford 3,4,4-trifluoro-3-butenoic (IV) acid in 52% overall yield. ##STR3##
후처리
- customare at a temperature of about 51-54° C
출처 및 근거
- ORD 기록
- ord-068be2ad91eb433193c459a5a1fa5139
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05968916
반응 노트
불러오는 중…