Water → 4-Benzylpiperazine-1-sulfonamide

HRID 1739737노트

반응식

HRID 1739737 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:14](N)([NH2:17])(=[O:16])=[O:15].O>O1CCOCC1>[NH2:17][S:14]([N:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1)(=[O:16])=[O:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 759941-BenzylpiperazineHCID 82267Sulfamide

생성물 1

HCID 112305864-Benzylpiperazine-1-sulfonamide수율 65.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 1-benzylpiperazine (5 g, 28.4 mmol) and sulphamide (2.77 g) in 1,4-dioxane (25 ml) was heated under reflux for 24 hours. The solution was cooled and poured into water (100 ml). The solid was filtered off, washed with toluene (100 ml) and dried under reduced pressure to give the title compound (4.75 g).

후처리

  1. temperatureunder reflux for 24 hours
  2. temperatureThe solution was cooled
  3. filtrationThe solid was filtered off
  4. washwashed with toluene (100 ml)
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ff5b110686c0465cad76b5e4ccf8d56d
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05968923

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