Methyl 3-(hydroxymethyl)-5-iodobenzoate → Methyl 3-formyl-5-iodobenzoate

HRID 1740306노트

반응식

HRID 1740306 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([I:13])[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[C:5]([I:13])[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:1]

참가 물질

4

반응물 1

HCID 21837989Methyl 3-(hydroxymethyl)-5-iodobenzoate

생성물 1

HCID 21838328Methyl 3-formyl-5-iodobenzoate수율 55.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

The mixture of methyl 5-hydroxymethyl-3-iodobenzoate (5.0 g) and manganese dioxide (30.0 g) in ethyl acetate (50.0 ml) was heated under reflux for 4 hours. The magnganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give methyl 5-formyl-3-iodobenzoate (2.77 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. customThe magnganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-8198add690444a2cb28721a0145655f5
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05968985

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