Sodium Carbonate → 4-(2-Methoxyethyl)piperazine-1-carbaldehyde
반응식
[CH:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=[O:2].C(=O)([O-])[O-].[Na+].[Na+].[CH3:15][O:16][CH2:17][CH2:18]Br>CO>[CH:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:18][CH2:17][O:16][CH3:15])[CH2:5][CH2:4]1)=[O:2]참가 물질
5
실험 절차
To a solution of 37.1 g of N-formylpiperazine and 37.1 g of anhydrous sodium carbonate in 50 mL of methanol was added dropwise 53.15 g of methoxyethyl bromide, and the mixture was refluxed for 3.5 hours. After cooling to room temperature, insolubles were filtered out and the filtrate was concentrated. To the residue was added water and chloroform. After separating the organic layer, the aqueous layer was extracted with chloroform. The combined organic layer was dried over anhydrous magnesium sulfate and concentrated to give 57.2 g of the title compound.
후처리
- temperaturethe mixture was refluxed for 3.5 hours
- filtrationinsolubles were filtered out
- concentrationthe filtrate was concentrated
- additionTo the residue was added water and chloroform
- customAfter separating the organic layer
- extractionthe aqueous layer was extracted with chloroform
- dry with materialThe combined organic layer was dried over anhydrous magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-aaaf1bfb69a940fe969a8ee59137fee5
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05969138
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