p-Toluenesulfonic acid monohydrate → HCID 86754641, 화합물

HRID 1740406노트

반응식

HRID 1740406 반응식
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:28][CH2:27]3)[C:21]2=[O:36])=[CH:16][CH:15]=1>C(OCC)(=O)C>[OH2:9].[OH2:34].[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:24][CH2:23][C@H:22]([CH2:25][N:26]3[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][O:34][CH3:35])[CH2:30][CH2:31]3)[C:21]2=[O:36])=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 9892249MS-377 free base

생성물 1

HCID 86754641HCID 86754641, 화합물수율 194.4%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of 380 mg of p-toluenesulfonic acid monohydrate in 10 mL of ethyl acetate was added a solution of 352 mg of (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone in 10 mL of ethyl acetate. The mixture was stirred at room temperature and cooled. The precipitated solid was filtered and dried to give 712 mg of the title compound.

후처리

  1. temperaturecooled
  2. filtrationThe precipitated solid was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-fda6ce23a59e4ff78afac8cf92d8a5bc
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05969138

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