2-Acetylbenzoic acid → 1-{2-(4-methyl-1(2H)-phthalazinon-2-yl)-4-pyridyl}-3-hydroxymethyl-6,7-diethoxynaphthalene

HRID 1740648

반응식

HRID 1740648 반응식
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:22][CH2:23][CH3:24])=[C:16]([O:19][CH2:20][CH3:21])[CH:17]=3)[CH:12]=[C:11]([CH2:25][OH:26])[CH:10]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[C:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[C:36]([CH3:38])=O)(O)=[O:28]>C(O)CO>[CH3:38][C:36]1[C:31]2[C:30](=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:27](=[O:28])[N:1]([C:3]2[CH:8]=[C:7]([C:9]3[C:18]4[C:13](=[CH:14][C:15]([O:22][CH2:23][CH3:24])=[C:16]([O:19][CH2:20][CH3:21])[CH:17]=4)[CH:12]=[C:11]([CH2:25][OH:26])[CH:10]=3)[CH:6]=[CH:5][N:4]=2)[N:2]=1

참가 물질

4

반응물 2

HCID 684742-Acetylbenzoic acidHCID 220073321-(2-Hydrazino-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene

생성물 1

HCID 220074411-{2-(4-methyl-1(2H)-phthalazinon-2-yl)-4-pyridyl}-3-hydroxymethyl-6,7-diethoxynaphthalene수율 87.5%

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

1-(2-Hydrazino-4-pyridyl)-3-hydroxymethyl-6,7-diethoxynaphthalene (177 mg), 1-carboxy-2-methylcarbonylbenzene (86 mg) and ethylene glycol (1 ml) are treated in the same manner as in Example 104-(3) to give 1-{2-(4-methyl-1(2H)-phthalazinon-2-yl)-4-pyridyl}-3-hydroxymethyl-6,7-diethoxynaphthalene (211 mg), which is listed in Table 14.

출처 및 근거

ORD 기록
ord-f73761e63860441cbd9bea45b61b0415
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05969140

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